One Times Square is a 25 story skyscraper, designed by Cyrus L. W. Eidlitz, located at 42nd Street and Broadway in New York City. The tower was originally built to serve as the headquarters of the local newspaper, The New York Times; however, the Times only stayed in the building for less than 10 years before it moved to a new building on 229 West 43rd Street.

Despite the Times leaving the building, One Times Square remained a major focal point of Times Square due to its annual New Year's Eve festivities, along with the introduction of an electronic news ticker at street-level in 1928. Due to the large amount of revenue that its ads pull, One Times Square is considered one of the most valuable advertising locations in the world.

Stewie's Calvin Klein commercial shown on the giant electronic billboard of One Times Square in "A Picture's Worth a Thousand Bucks".