Stewie Cruise

Oprah Gail Winfrey (born January 29, 1954) is an American media personality, Academy Award nominated actress, producer, literary critic and magazine publisher, best known for her self-titled, multi-award winning talk show, which has become the highest-rated program of its kind in history. She has been ranked the richest African American of the 20th century.

Stewie Griffin gets a book from Oprah's book club in "PTV" although he tries to deny it.

In "Deep Throats", Stewie Cruise goes on the The Oprah Winfrey Show and professes his love for Katie Holmes, jumping on the couch in a parody of Tom Cruise on Oprah's show.

Carter Pewterschmidt convinces Brian Griffin to sell out his views on marijuana in "420" by promoting his novel, Faster Than the Speed of Love though Oprah's book club endorsement and selection but while the attempt was successful, the book still was a failure.

In "Peter-assment", she was the fourth of the five black celebrities that Peter Griffin makes fun of Ollie Williams.

A DVD exclusive scene in "Excellence in Broadcasting" features Lois Griffin asking Rush Limbaugh who would win in a fight between him and Oprah. Rush claims it was a draw after they wiped out most of downtown Tokyo.