Pac-Man is the main character from the arcade game developed by Namco and licensed for distribution in the United States by Midway, first released in Japan on May 22, 1980. His partner, Ms. Pac-Man, appears in several related media
In a cutaway in "Stuck Together, Torn Apart", Peter compares his trial separation from his wife Lois to the divorce of Mr. and Ms. Pac-Man. Three of the ghosts, Blinky, Clyde, and Funky visit Pac-Man to cheer him up afterwards. Pac-Man, who took up smoking, doesn't attempt to consume them, even after the ghosts turn vulnerable.
Also, in "Road to the Multiverse", in one of the opening scenes, Brian can be seen playing Pac-Man with Stewie as Pac-Man and the rest of the family as the ghosts.
When Peter describes Briggs' legs being shot in "Joe's Revenge", he imitates the sound effect from the video game Pac-Man when the player touches a ghost.