The title is a reference to the film "Terms of Endearment".
Brian spoofs the Cowardly Lion from The Wizard of Oz then he tries to stay in the house when he finds out Lois' friend Naomi is the one coming over to see Lois.
When Lois is about to have the embryos implanted, Dr. Hartman tells her that the procedure will be performed by a group of Peruvian natives. However, Lois then says she does not want this method of procedure, Dr. Hartman replies, "Well, perhaps you could tell them. If only you spoke Hovitos." This is a reference to the film Raiders of the Lost Ark.
The anti-abortion film Abortion Madness! is a parody of Reefer Madness, a 1936 American exploitation film revolving around the tragic events that ensue when high school students are lured by pushers to try "marihuana" which is considered comical today.
The scene where Peter lures Lois out to the desert with DVD's of Grey's Anatomy and how his trap backfires is a reference to Looney Tunes characters, Wile E. Coyote and Road Runner. Also the Miscarriage Kit is from ACME.