Pewterschmidt Industries is part of Carter Pewterschmidt's business empire. In "Running Mates" it is also said to be involved in shipping. In "Business Guy", son-in-law Peter Griffin takes over the business when Carter slips into a coma and introduces new products such as The African-American Heart Monitor and Jeremy Irons Cereal.

Brian and Stewie follow Carter to Pewterschmidt Industries when Brian suspects Carter is an impostor, but discover he his withholding a cure for cancer from their pharmaceuticals lab in "The Old Man and the Big 'C'".