The Predator is a fictional extraterrestrial species featured in the Predator science-fiction franchise, characterized by its trophy hunting of other dangerous species for sport, including humans and its fictional counterparts, Aliens.

First introduced in 1987 as the main antagonist of the film Predator, the Predator creatures returned in the sequels Predator 2 (1990), Alien vs. Predator (2004), Aliens vs. Predator: Requiem (2007), and Predators (2010). The Predators have also been the subject of numerous novels, video games, and comic books, both on their own and as part of the Alien vs. Predator crossover imprint.

Kramer vs. Predator pits Dustin Hoffman’s character from Kramer vs. Kramer against a Predator in a parody of the 2004 crossover film Alien vs. Predator in "8 Simple Rules for Buying My Teenage Daughter".

In a cutaway gag in "Brian Writes a Bestseller", a guy in a coma dreams of writing a script of Batman vs. Predator.

A Predator stalks Peter, Joe and Quagmire in the woods in "Bigfat". Peter suggested covering their body heat like Arnold Schwarzenegger did in the film but the others disagree; saying it's just a movie.