Q*bert is a mushroom-shaped creature featured in the 1982 Atari game of the same name.
In "Chick Cancer", Stewie Griffin claims that being his roommate was easier than being married to Olivia Fuller. Stewie is seen sleeping on the isometric game field, annoyed by Q*bert's incessant playing. As Q*bert gets on each square, it lights up, disturbing his sleep. Stewie then screams that if it continues, Q*bert must pay the entire electric bill.