Quahog Fire Station No. 5 is the site of an open house in "Ratings Guy" as well as where Peter and Lois attempted to abandon Meg as a newborn. Fire Captain Beckman has to contend with Joe Swanson who ridicules the fire fighters for having hoses instead of guns and shoots the tires of their firetruck as he says he'll see them of the softball field. Beckman later demonstrates how they used to fight fires with their bare hands but the fire turns on him and shoots him twice before turning the gun on itself.

During the afterparty in Stewie Griffin: The Untold Story, Peter explains about having a series of part-time jobs after Family Guy was canceled including as a firefighter at Quahog Fire Station No. 5,