Quahog Harbor is a major port-of-entry for shipping in Quahog.

The family smuggle themselves back from Italy through the harbor by posing as sex dolls in "Boopa-Dee Bappa-Dee".

Quagmire buys a condo at Prescott Towers from Brian in "Brian the Closer", only to discover that it is a run-down dump as a neighbor warns him that the harbor is poisoned.

When Peter is caught by Joe with possible child porn on his laptop computer in "The 2000-Year-Old Virgin", he rushes the laptop to the harbor and dumps it far offshore.