The Quahog Mini-Mart is the local gas station and convenience store managed by Carl and, as of "Movin' Out (Brian's Song)" Chris Griffin's current place of employment.

At various times, Kevin Swanson, in "Fifteen Minutes of Shame", and Meg Griffin, in "Movin' Out (Brian's Song)", were employees. Brian Griffin sometimes buys his cigarettes here, such as in "Mother Tucker". In "Deep Throats", Brian and Stewie bought doughnuts from here to eat while investigating Mayor Adam West.

During the afterparty in Stewie Griffin: The Untold Story, Lois explains about having a series of bad encounters after Family Guy was canceled including attacking a clerk at the Mini-Mart.

Carl is very afraid of being sued, such as in "Baby Not On Board" when Peter threatened to do so, so he would give away an unlimited gas card to the potential plaintiff. In "Road to the North Pole", Carl expressed his wish for a Blu-ray copy of The Wiz here during the song "All I Really Want For Christmas"

Brian plants a fake lottery ticket at the store with Queen's News o the World album art in order to scare Stewie in "Killer Queen".

Meg comes looking for a runaway Chris at the Mini-Mart in "Chris Cross", as a half-naked Mayor Adam West flashes the place and makes his escape in a getaway car driven by Seamus.