The Quahog National Bank is where Mort Goldman seeks refuge after seeing a mob coming for Peter Griffin after he screws up television in "Ratings Guy". Mort and other Jews use Menorahs as jet packs to land on the safety of the bank roof.
Peter and Lois get a loan from the bank in "Baking Bad" to open a store together, Peter's Wife's Cookies. They luckily discover that Cookie Monster is the loan supervisor. Lois is able to get out of the loan by giving the store back to the bank where Cookie Monster happily munches Cookie, one of the bikini-clad help.