RMS Titanic was a British passenger liner that sank in the North Atlantic Ocean in the early morning of 15 April 1912 after colliding with an iceberg during her maiden voyage from Southampton, UK to New York City, US. The sinking of Titanic caused the deaths of more than 1,500 people in one of the deadliest peacetime maritime disasters in modern history. Under the command of Captain Edward Smith, the ship's passengers included some of the wealthiest people in the world, as well as hundreds of emigrants from Great Britain and Ireland, Scandinavia and elsewhere throughout Europe seeking a new life in North America.

After being called a moron by Stewie in "Stewie, Chris & Brian's Excellent Adventure" for failing to learn any history on a trip through time, Chris boards the Titanic with their Time Machine return pad. Stewie and Brian climb a mooring rope and find him in a dining room just as the ship strikes the iceberg, damaging the return pad. They attempt to pose as female passengers, but are denied access to the last lifeboat. Chris bulls his way past Nigel Harpington, the officer in charge and the boys escape from the ship to find time to repair the pad. On returning to the present, Stewie checks a "Titanic Casualties" web site and discovers that passengers Cornelia Andrews, Elizabeth Bonall, William Carter and Alice Fortune are listed as deceased, but by killing Nigel they had made a slight alteration to the present that results in Chris getting a new teacher that doesn't believe in tests.