Raiders of the Lost Ark (also known as Indiana Jones and the Raiders of the Lost Ark) is a 1981 American action-adventure film directed by Steven Spielberg, produced by George Lucas, and starring Harrison Ford. It is the first film in the Indiana Jones franchise; and it pits Indiana Jones (Ford) against the Nazis, who search for the Ark of the Covenant, because Adolf Hitler believes it will make their army invincible. The film co-starred Karen Allen as Indiana's former lover, Marion Ravenwood; Paul Freeman as Indiana's nemesis, French archaeologist; René Belloq; John Rhys-Davies as Indiana's sidekick, Sallah; and Denholm Elliott as Indiana's colleague, Marcus Brody.
Brian escapes from police officers by hiding in a giant wicker basket like Marion Ravenwood did in the film in "Brian: Portrait of a Dog".
In "Jungle Love", when the natives discover that Chris is a freshman, they chase the Griffin family in the same manner as the Hovitos chased Indiana Jones. Jones' pilot, Jacques is shown as he was depicted in the film and music from the soundtrack was played. They escaped, except for Meg, who died the same way that the guide did.
In "Blind Ambition", Peter and Ernie the Giant Chicken reenact the fight between Indiana Jones and the giant Nazi and Ernie seemingly dies the same way as the Nazi with the airplane propeller.
In "Partial Terms of Endearment", the artificial insemination is performed by Hovito, a fictional race from the film. Dr. Hartman says: "Well, perhaps you could tell them. If only you spoke Hovitos." just as Belloq did to Jones.
According to the Fact Ups for Something, Something, Something, Dark Side, R2-D2, played by Cleveland Brown, was going to pass the time it takes to get to Dagobah by listening to a novelization-on-tape of the film. This was replaced by two travelers asking Luke Skywalker, played by Chris Griffin, for directions.
Peter wants to finish the murder trial of Mayor Adam West in "12 and a Half Angry Men" so he can get back to the Director's cut of Raiders. A cutaway shows Marion revealing she is pregnant as the Holy spirits kill the Nazis for looking into the Ark and Indy suggests she take a quick peek.
The delivery driver collapsing after being shot in the back with several poison darts in "Mr. and Mrs. Stewie" is similar to the death of Barranca at the hands of the Hovitos in Raiders.