This episode reveals that Brian was born in Austin, Texas.
The radio in the car Brian and Stewie steal plays “Do You Really Want to Hurt Me?” by Culture Club which Stewie says he likes when Brian reaches for the radio.
Stewie thinks his phone number is 867-5309 thanks to the Tommy Tutone hit “867-5309/Jenny”.
The Pewterschmidt's are shown to have a vacation home in Palm Springs.
While eulogizing Brian’s mother, Stewie gives an unusual retelling of the Biblical story of Abraham and Isaac.
This has been referred to by Seth MacFarlane as “everybody’s favorite episode” mainly by its revelation of Brian’s history and using the song and dance number to show the bickering yet close relationship of Brian and Stewie.
During the singing of "Road to Rhode Island", Brian appears as a pitcher in one scene. As he turns around to pitch, his shirt says "Red Sox 86" on the back. The Red Sox previous World Series appearance was a losing effort in 1986. In a bit of irony, when the Red Sox won their World Series in 2004, it came exactly 86 years after they won their last one. This episode first aired in 2000.
While driving, Stewie and Brian play Six Degrees of Kevin Bacon, a game in which people link an actor or actress to Kevin Bacon by six or less films.
Stewie asks Brian to tape the episode of The Brady Bunch where Bobby saves Greg’s life and Greg becomes Bobby’s slave. However, it was actually Peter whose life Bobby saved in that episode (“My Brother’s Keeper”).
A scene in this episode featured Osama bin Laden that only aired once: Stewie sings “On the Good Ship Lollipop" to distract airport baggage handlers from noticing the weapons in his luggage, then remarks, “Let’s hope Osama bin Laden doesn’t know show tunes.” The camera pans to show bin Laden singing “I Hope I Get It” from the musical A Chorus Line as his luggage goes through the detector. This episode aired more than a year before the September 11th terrorist attacks. The entire scene was taken out of the episode in subsequent airings and the Region 1 “Volume 1” Family GuyDVD set although the scene remains intact up until Stewie’s singing in the Season 2 DVD set for Regions 2 and 4, but can be seen on the Family Guy: The Freakin' Sweet Collection DVD. In the DVD commentary, Seth MacFarlane mentions that the moral is that “the FBI should watch Family Guy more often.”