• The genetically perfect pig's collar changes from red to black between when Brian and Stewie leave the fair and when Brian and Stewie get to Stewie's room.
• In the universe where everyone has two heads, the Griffin house has a picture on the wall of Chris with only one head.
• Brian's dog tag briefly disappears in the fire hydrant universe.
• In the first universe they visit, chapels seem to exist despite the lack of Christianity.
• In the Ice Age universe, Brian presses the button with his tail, however, in the next universe Stewie is holding it again. This universe was a last-minute substitution. The '1980s Bullies' universe was intended in this place originally.
• Before human Brian jumps into the portal, dog Stewie was nowhere to be seen, but appears when human Brian jumps into the portal
• In the universe where everyone has two heads, we first see a yellow house behind Stewie and Brian and then Cleveland's pink house- then back to the yellow house and back to Cleveland's pink house once again.
• Stewie says he'll blow Brian's mind like the steropticon did in 1910, misnaming the stereoscope for the stereopticon, a common mistake. [1]

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