• This is the 7th of the Road to... episodes.
  • This is the third episode involving cloning where Brian or Stewie are cloned. The first being "Quagmire's Baby" and the other being "The Hand That Rocks the Wheelchair".
  • This is the second "Road to..." episode composed by Ron Jones after "Road to the North Pole".
  • This is the second "Road to..." episode not to contain a showstopping musical number after "Road to Germany".
  • This is the second time in the entire series where Brian considers committing suicide after "Brian & Stewie", but it's the first time that he actually does it.
  • "Luck Be a Lady" by Frank Sinatra plays while Lucky Stewie and Brian go around Las Vegas.
  • The "Dyslexic Baseball Wrap Up" from "The Giggity Wife" is playing on the sports book television unlucky Stewie and Brian watch just as the camera turns around to focus on the lucky pair.
  • Brian is seen trying to get into Heaven despite being an atheist.
  • Peter is shown to have a prominent tell when playing cards but in "Screwed the Pooch" he is shown to have a great pokerface, allowing him to excel at cards.
  • Steve Callaghan called the scene where Stewie and Brian consider joint suicide the hardest scene for him to write this year. [1]
  • Although the FOX press release states that Brian and Stewie use the time machine to travel to Las Vegas, the episode actually features Stewie inventing a teleportation device. It also states that Brian and Stewie go to Las Vegas to see a Bette Midler concert, they actually go to see Celine Dion.[2] The DVD commentary reported that neither were ever actually scripted as such.
  • The DVD commentary also notes that in the cutaway gag in which Peter gets an extended summer, when he tears off his shirt, all of his clothes, including his shoes, "magically" fly off as well as part of the comic effect.
  • Despite the apparent hit on Principessa, the DVD commentary for "Quagmire's Quagmire" notes that her fate is not necessarily resolved.

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