Robot Chicken is a program on Cartoon Network's Adult Swim which was co-created by Seth Green. The program features stop-motion animation of action figures in various skits and shorter vignettes, similar to Family Guy cutaway gags. It premiered on February 20, 2005. Since airing, several episodes have featured a nerdy school boy who is voiced by Green in the same way he'd perform Neil Goldman.

During the final minutes of Blue Harvest, Peter and Chris Griffin have a debate about the program, which had previously parodied Star Wars. Peter claims it's not a real TV show since it's on Cartoon Network, while Chris, voiced by Seth Green, defends the show. The argument is rekindled in Something, Something, Something, Dark Side.

In It's A Trap! the Emperor and Vader are criticizing the career of Seth Green to turn Luke over to the dark side of the Force.

In "Road to the Multiverse", Stewie and Brian travel to the Robot Chicken universe where Stewie makes a joke about the show being on Cartoon Network by asking the Robot Chicken versions of Peter and Chris how it feels to be on a major network (FOX) for thirty seconds which makes Chris mad..