Ronald McDonald is the main symbol for McDonald's fast-food restaurant chain. He is a clown character used as the primary mascot of the McDonald's fast-food restaurant chain. In television commercials, the clown inhabits a fantasy world called McDonaldland, and has adventures with his friends Mayor McCheese, the Hamburglar, Grimace, Birdie the Early Bird, and The Fry Kids. In recent years, McDonaldland has been largely phased out, and Ronald is instead shown interacting with normal kids in their everyday lives.

In "Fifteen Minutes of Shame" he is shown to be a rather strict parent, scolding his daughter, Lisa McDonald, for wearing way too much makeup. He is voiced by Seth MacFarlane.

In "Petergeist", the Griffins' house was haunted, and McDonald was scaring Chris Griffin by making the McDonald's symbol with his hands, scaring Chris.

Peter's outfit in the Quentin Tarantino segment of "Three Directors" is a homage to Ronald McDonald.