Roxane is the female lead in the play Cyrano de Bergerac that Cyrano falls in love with. Unable to express his love out of fear of his appearance, Cyrano enlists the aid of his friend Christian to help woo Lady Roxane.

In "Love, Blactually", Cyrano seems to have more troubles than just his large nose with trying to woo Roxane.

When Peter and the guys form a neighborhood watch in "A Shot in the Dark", they discover de Bergerac hiding in the bushes and start to beat him, while Christian continues reciting his pleas for help. However, this works with Roxane who invites him to come to her, while her own proxy requests that he bring pound cake. In this appearance, Roxane is voiced by Rachael MacFarlane.