Rubik, the Amazing Cube was a Saturday morning cartoon that aired from September 10, 1983–September 1, 1984 in the United States. The show featured a magic Rubik’s Cube named Rubik who could fly through the air and had other special powers. Rubik could only come alive when the colored squares on his sides had been matched up. It is based on the Rubik's Cube, a 3-D combination puzzle invented by Hungarian Ernő Rubik. The puzzle was licensed by Rubik to be sold by Ideal Toy Corp., becoming a fad during the 1980s.

Tom Tucker compares the clitoris to a Rubik's cube in a news story in "Running Mates".

In the uncensored version of "Peter-assment", Peter Griffin confronts Rubik outside of a bar over his drinking problem. Rubik denies this and tries to solve himself, settling for peeling off his stickers and attempting to rearrange the colors without solving the cube.