Sábado Gigante ("Giant Saturday") is a Spanish-language television show that was Univision's longest-running program and the longest-running variety TV show in the world, running for 53 years before ending in 2015. Sábado Gigante is an eclectic and frenetic mix of various contests, human-interest stories, and live entertainment.

In "Stewie Loves Lois", during an argument with Brian, Stewie starts arguing in Spanish. Stewie attributes this to falling asleep while watching Sábado Gigante, followed by an animated cutaway of the show.