San Francisco is the cultural, commercial, and financial center of Northern California.

Quagmire invites the guys to go along on a flight to San Francisco in "Passenger Fatty-Seven". Among the sites they visit are:

  • Ghirardelli Square, a landmark public square with shops and restaurants originally home to the Ghirardelli Chocolate Company.
  • Lombard Street, notable for a steep, one-block section with eight hairpin turns, claimed as "the most crooked street in the world."
  • The Golden Gate Bridge
  • The Headquarters of Levis Strauss
  • Fishermen's Wharf where the guys ride Segways.