Sandra is a woman that Quagmire meets at The Drunken Clam in "The Dating Game".

As he tries to drink away his sadness after becoming a husk of a man due to his use of Tinder, Sandra tries to strike up a conversation but is rebuffed. After a discussion with his inner selves about his loss of sex skills, he gins new confidence in himself and spins a yarn about a dead twin brother, getting Sandra to go home with him.

After they leave, the guys believe that she is the hooker they paid to help Quagmire gain his confidence back, but when the real hooker shows up, they fear that Sandra is really a murderer and that Quagmire will be killed, although they blow it off to kick soccer balls at the hooker that they make full-time goalie.