Santos and Pasquel are Portuguese immigrants who used to work as fishermen with Peter Griffin. They are a reference to the large Portuguese-American community located in southeastern Massachusetts and Rhode Island, which would include Quahog. One was a cardiologist in Portugal. They do not speak a word of English, even when talking to those who do. Eventually, in "The Perfect Castaway" Peter couldn't afford them, so he decides to shoot them, fortunately they realize this and swim away in time.
While talking about Santos & Pasquel who were Portuguese in "Screams of Silence: The Story of Brenda Q.", Peter claims that he always though of geese on a porch. Peter also referred to them as "Portuguese Consuelas".