Scooby-Doo is an animated series produced for Saturday morning television in several different versions from 1969 to the present. The original series, Scooby-Doo, Where Are You!, was created for Hanna-Barbera Productions and has produced numerous spin-offs and related works until being absorbed in 2001 into Warner Bros. Animation. They have handled production since then. All versions of the show feature a talking dog named Scooby Doo; the original series included four teenagers or young adults: Fred "Freddie" Jones, Daphne Blake, Velma Dinkley, and Norville "Shaggy" Rogers. These five characters are officially and collectively known as "Mystery, Inc.".
In "I Never Met the Dead Man", Peter wonders what Scooby and the gang are up to on The Scooby Doo Murder Files, where Mystery Inc. gets to solve murders after he knocks out television in Quahog. Frank Welker reprised his role of Fred.
They also appear in "Family Guy Viewer Mail No. 1" segment "Lil' Griffins".
Scooby is mentioned in Family Guy: Live in Vegas.
"Business Guy" parodies Scooby-Doo when Carter and Lois run from a swamp monster, using the music, sound effects, and style of the original chases from the 1969 series, in the end they unmask the monster after catching him in a net.
Peter references Scooby-Doo in "Grumpy Old Man" when he accuses a resident at the Oceanside Retirement Community of being "old man Withers who runs the haunted amusement park." When he tries to unmask him, he tears the old man's face off.