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Scrappy Brian is Brian's nephew.
When Brian is forced to sleep outside after getting sprayed by a skunk in "Meg Stinks!", he points out to Peter and Meg that Scrappy didn't make it through the night. In a cutaway, Scrappy and Brian hear a noise. Although Brian would rather be cautious, Scrappy charges at it and is eaten by a velociraptor. Brian notes that he told his sister that it wasn't a good weekend for Scrappy to visit.