This episode involves a crossover plot of a hurricane affecting all three current Seth MacFarlane shows including American Dad! in "Hurricane!" and The Cleveland Show in "The Hurricane". It is a parody of a stunt used by NBC on November 9, 1991 alternately called Night of the Hurricane and Hurricane Saturday involving a hurricane simultaneously affecting the sitcoms The Golden Girls, Empty Nest, and Nurses. Although no characters from either The Cleveland Show or American Dad! appear in this episode, Cleveland and Peter do appear in "Hurricane!"
The three episodes of "The Hurricane", "Hurricane!", "Seahorse Seashell Party" aired about a month after Hurricane Irene, which affected both Virginia and Rhode Island.
This episode was originally set to air on May 1, 2011, but was pulled in light of tornadoes in the Southern U.S. a few days prior.
The movie Peter tries to interpret in charades is Fletch.
In a case of life imitating art, "STEWIE JUST SAID THAT" trended in the United States on Twitter after Act Two where Stewie said that everyone was tweeting "Stewie just said that".
Meg breaks the fourth wall by pointing out, that if Family Guy would be true, Peter would go to prison for abusing her. Likewise, Stewie notes that everyone is on Twitter with his "Stewie Just Said That!".