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- Peter previously became a shill for the D.C. tobacco lobbyists in "Mr. Griffin Goes to Washington".
- Joan had previously found a carton of cigarettes in Peter's bellybutton while working as his maid in "I Take Thee Quagmire", and Peter previously smoked during a cutaway break in "Back to the Pilot" and in a second cutaway gag in "Family Goy".
- A cutaway gag depicts an owl responding to Abbott & Costello's signature comedy bit "Who's on First" by asking "Who?" to every question poised by Lou Costello.
- Peter says to have watched every single YouTube video, and that there is not a bad one on the site.
- Lois quickly accepts Dr. Hartman's offer to go away in exchange for the narcotic drug Vicodin. She also proposes getting a couple of bottles of wine after visiting the stop smoking clinic.
- In a cutaway gag, an elderly Stewie considers Katy Perry and Justin Bieber "real music."
- Peter Dinklage is credited as the voice of Mr. Stone in "Secondhand Spoke" in the official FOX press release. However, he is not included in the on screen credits in the role which is performed by John Viener. The DVD commentary for "Christmas Guy" mentions that a big-name actor was replaced this season after reading the role when it was felt it didn't work out.