Sigourney Weaver (born October 8, 1949) is an American actress. She is best known for her roles as Lieutenant Ellen Ripley in the Alien film series and as Dana Barrett in the Ghostbusters movies. Weaver is also a three-time Academy Award nominee for her performances in Aliens, Gorillas in the Mist, Working Girl, and Avatar. She is still one of the very few actresses who has ever been nominated for an Academy Award for Best Actress for her role in a science fiction movie in Aliens.

In "Peter's Daughter", her character's escape from the Xenomorph Queen at the end of Aliens is parodied.

In "Grumpy Old Man", The Griffins and the Pewterschmidts are shown a theater at the Oceanside Retirement Community where the film can be stopped by pressing a button on the seat so the patrons can ask questions. While watching Avatar, one of the residents mispronounces her name but notes that Sigourney Weaver's character is smoking but is still a handsome woman.