Plot: During a backyard party at the Swansons' house, Stewie gets into a fight with Joe's baby daughter Susie, who beats him up. Ashamed by the fact that his own son got beaten up by a girl, Peter takes Stewie to the Quahog Boxing Gym to learn how to be a man. One of the instructors at the gym gives Peter some steroids to give to Stewie, who becomes incredibly buff and macho as a result. With his newfound girth, Stewie begins to revel in bossing Brian around until the steroids wear off, making his skin incredibly loose and flabby. Stewie jumps out of his bedroom window to avoid Brian's wrath, only to have his loosened skin help him glide to safety. By the end of the episode, his body seems to have returned to normal.
Meanwhile, Connie D'Amico, the most popular girl at school, has hooked up and broken up with every popular boy in school, so she goes out with Chris with the intent of making him popular before breaking up with him. However, when they go out, Chris honestly falls in love with Connie, something no other boy has done with her. Connie decides to stay with Chris, but his newfound popularity goes to his head and he starts cheating on her. Now unpopular, Connie teams up with Meg, who Chris had not invited to a party at their own house, and they publicly show a video of him dancing like "Buffalo Bill" from The Silence of the Lambs, destroying his popularity. Chris makes up for his behavior to Meg by vividly describing how wonderful it felt to be popular.