During the first scene at Connie DiMico and Chris' party, Peter holds up a coin with holes in it, a reference to the Spanish doubloon that the character Mikey Walsh uses in the film 'The Goonies to locate One-Eyed Willy's hidden treasure.
After Stewie is introduced to the steroids, he picks up the barbell and says "I have the power". This is a reference to the cartoon/film hero He-man, where he lifts his power sword over his head and says "I have the power".
At one point, Stewie flies and lands on a mailbox and says, "And now here's something we hope you'll really like." This is a reference to The Rocky and Bullwinkle Show
Stewie sings a song and pronounces the word "body" like "bah-dy", like how John Mayer sings it, referencing his song "Your Body is a Wonderland".
When busted for drunk driving, Santa Claus asks if the arresting officer is Jewish, the same as Mel Gibson did when he was also arrested for drunk driving.
The video of Chris Griffin that is played in the school, where he uses lipstick and dances, is a reference to the film The Silence of the Lambs, in the scene where Buffalo Bill, the transsexual serial killer, performs the same dance. The song played is "Goodbye Horses" by Q Lazzarus.