Stewie Kills Lois/Notes/Trivia
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- This episode was intended to be the season five finale, but due to extended contract negotiations, production was halted and the episode was not completed in time.
- A half-hour retrospective on the first 100 episodes of Family Guy, titled "The Family Guy 100th Episode Special", preceded the original airing of the episode.
- The title of this episode is an ironic play on the title of the first episode of season five.
- This was celebrated as the 100th episode of Family Guy.
- Stewie unknowingly arouses Brian while describing bondage to him.
- The Kool-Aid Man makes yet another appearance, in a direct homage to his courtroom intrusion in "Death Has a Shadow".
- During one of his dates, Peter says that his astrological sign is Leo. However in the "The Fat Guy Strangler, Dr. Hartman said that Peter's astrological sign was a Cancer.
- In this episode it is revealed that Meg was going to be aborted.
- Peter warns Brian to stay out of the cat box, suggesting an unseen family cat
- Ringo Starr did write or help write a few songs for the Beatles, including "Octopus Garden", co-written with Harrison.
- It is revealed that Quagmire used to be a stand-up comedian and had longer hair.
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