• Stewie's disappointment regarding his parents' departure is compared to his disappointment from seeing The Lake House.
• Peter gets in trouble for defecating on the poop deck.
• Lois references Kate Winslet's character Rose DeWitt Bukater, calling her "that fatass British girl from Titanic." Peter thinks she's mistaken and tells her that the character was not played by Winslet, but by Philip Seymour Hoffman.
• When Stewie thinks to himself, he references "Pigs in Space" which is a classic sketch from The Muppet Show.
• Brian watches a film in which Harrison Ford tells random people he wants his family back. Harrison's movies frequently have this type of theme, such as the movies Air Force One, The Fugitive, Firewall, Frantic, Patriot Games, and Random Hearts.
• Meg holds a package of hot dogs, telling them she's going to pretend they're the New York Knicks.
• Quagmire calls Peter a killer, like Bernie Goetz, which he did a bit of stand-up comedy on.
• Herbert asks Stewie to tell Chris to open his window and holds above him an old style phonograph which is playing Let's Have Another Cup Of Coffee by Irving Berlin performed by Glenn Miller . It's somewhat of a reference to a scene in Say Anything... where John Cusack's character holds up a boombox playing In Your Eyes by Peter Gabriel for Ione Skye's character.
• Lois' return at the end resembles the first appearance of the White Ranger of the Mighty Morphin Power Rangers.
• The poster promoting this episode is a parody of the movie poster for "Mr. and Mrs. Smith", starring Brad Pitt and Angelina Jolie.
• Peter listens to "Hello" by Lionel Richie.
• Tom Tucker concludes the news by saying, "That's the news and I...am...outta here!" and scribbling on his script. This was how Dennis Miller concluded "Weekend Update" when he was the head anchor of it on Saturday Night Live.
• The "To Be Continued" card is the same style and font as in two-part episodes of Star Trek: The Next Generation. The drawn out, dramatic music is a parody of the cliffhanger from the episode The Best Of Both Worlds Part 1. Ron Jones composed both the music for that episode and this episode.

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