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- This is the third episode to have the name Joe in the title following "Believe It or Not, Joe's Walking on Air" and "Joe's Revenge".
- In a cutaway gag, Gene Shalit's wife is named JoAnne. In reality, he is a widower and his late wife's name was Nancy.
- This is Mike Desilets first solo writing credit.
- Tom Petty And The Heartbreakers' "Runnin' Down A Dream" plays when Brian experiences a runner's high.
- "Sirius" by The Alan Parsons Project plays during the laser introduction of The Hopeful Squirrel 2.
- A week after this episode aired, Bono revealed the real reason he wore sunglasses was because he was going blind from glaucoma.