The Breakfast Club is a 1985 American teen film written and directed by John Hughes. The storyline follows five teenagers each representing a different clique in high school as they spend a Saturday in detention together and come to realize that they are all deeper than their respective stereotypes.

In "Let's Go to the Hop", Peter Griffin goes to detention and passes the library, and screams at the sight of The Breakfast Club. However, instead of the gang from the 1985 teen movie, he sees several breakfast cereal mascots including Toucan Sam, Tony the Tiger, the Trix Rabbit, Lucky the Leprechaun, and Cap’n Crunch. In addition, the song "Don't You (Forget About Me)" by The Simple Minds, which plays at the end of the film, plays at the end of the episode.

The DVD extended edition of "And Then There Were Fewer" features Seamus asking Dr. Hartman and Herbert if they'll still be friends the next day in class, parodying a scene from the film.

In "The Peter Principal", Peter addresses his family as The Breakfast Club, while they're eating breakfast.