The Karate Kid is a 1984 American martial arts romantic drama film directed by John G. Avildsen and written by Robert Mark Kamen, starring Ralph Macchio, Noriyuki "Pat" Morita and Elisabeth Shue. The original film has been followed by several sequels, an animated television series and remakes.

Peter refers to Lois's Tae-Jitsu teacher Jared Fellows by calling him Ralph Macchio in "Lethal Weapons".

After Stewie is released from his bubble in "The Father, the Son, and the Holy Fonz", he says to Brian that he and his friends at Cobra Kai will take him down, referring to the name of the gang of bullies in The Karate Kid.

When Derek Wilcox heals the waiter's elbow in "We Love You, Conrad", he does it in a similar way to the way Mr. Miyagi heals injuries in the original Karate Kid film.

Rush Limbaugh battles against the multicultural street gang in a parody of The Karate Kid in "Excellence in Broadcasting".

Chris is anxious to return from Italy in "Boopa-Dee Bappa-Dee" so he can see The Karate Kid V. In the following cutaway, an aging Daniel asks Mr. Myagi for help with his erectile dysfunction.

In "The Most Interesting Man in the World", the guys catch a more realistic version in which Ralph Macchio mouths off at Johnny for trying to cripple him.

The Karate Kid is parodied in "Once Bitten" as 80s Teen Movie at a Realistic High School where the real kids think performing karate makes the guys losers.