The New Yorker is an American magazine of reportage, commentary, criticism, essays, fiction, satire, cartoons and poetry published by Condé Nast Publications. Starting as a weekly in the mid-1920s, the magazine is now published forty-seven times per year, with five of these issues covering two-week spans.

Although its reviews and events listings often focus on the cultural life of New York City, The New Yorker has a wide audience outside of New York. It is well known for its commentaries on popular culture and eccentric Americana; its attention to modern fiction by the inclusion of short stories and literary reviews; its rigorous fact checking and copy editing; its journalism on world politics and social issues; and its single-panel cartoons sprinkled throughout each issue.

In "Brian Goes Back to College", the magazine offers Brian a job here following his report on a Quahog 1980s TV convention in a local newspaper. The magazine fires him on his first day upon the revelation that Griffin dropped out of college. Employees include Amelia Bedford Furthington Chesterhill, Wellesley Shepherdson, Livingston Winstofford, Fielding Wellingtonsworth, and James William Bottomtooth III. All employees are socialites of the upper case, all having three tier names. The restrooms of the building all have armchairs, actual toilets being unneeded since no one working for The New Yorker has an anus.

Brian brings up working for The New Yorker in "Dial Meg for Murder" when talking to an editor for Teen People magazine.