The Silence of the Lambs is a 1991 crime horror film starring Anthony Hopkins and Jodie Foster. Foster played FBI agent Clarice Starling who tries to find Buffalo Bill, a serial killer who kidnaps young women, imprisons them,and kills them. The film was nominated for seven Academy Awards and won five including Best Picture and Best Actress for Foster.
Chris' voice is inspired by Ted Levine's Buffalo Bill character in The Silence of the Lambs. 
In "Stuck Together, Torn Apart", Brian and Stewie find a little girl trapped in a well and Stewie looks down and quotes Buffalo Bill's repeated line: "He rubs the lotion on its skin or else it gets the hose again."
In the DVD cut of "And Then There Were Fewer", Stewie asks Brian who the star of the film was and Brian replied: "Tony Hopkins"; thinking he knew Hopkins on a first name basis.