The flashback showing Brian’s college years, during which he was harassed for being a dog, parodies the film School Ties, in which Brendan Fraser’s character is harassed for being Jewish although in the movie, the message on the wall read “Go Home, Jew!” instead of “Go Home, Dog!”.
The guard at the Dean’s office shouts, “Nobody sees the Dean, not nobody, not no how,” a reference to the Wizard’s guards in The Wizard of Oz.
Lois says that, when she was in college, the National Guard shot some of her friends, referencing Kent State during the 1970 shootings on the campus.
Peter says that he wanted to name Meg after Twiki, a robot from the 1970s television show Buck Rogers in the 25th Century.
When Meg goes to interview Mayor West, he asks her if she is Sarah Connor, a character from The Terminator.
When Peter’s typing on the typewriter, the camera pans around him, then he tosses the paper from the typewriter, where it then forms the logo for Stephen J. Cannell Productions.
After holding an exploding bomb from Mayor West, Meg has Daffy Duck’s bill on the wrong side of her head, and then states, “Of course, you realize, this means war,” parodying a frequent gag on Looney Tunes.
Stewie uses his mind control device to force Chris to sing “Puttin' on the Ritz” by Irving Berlin. This refers to a scene in Mel Brooks’ Young Frankenstein where the monster performs the same song.
After his mind control device short-circuits and Stewie is chased by Chris, he eludes him by disguising himself in a trenchcoat and sunglasses resembling Ferris from the film Ferris Bueller's Day Off.
A scene from Big is parodied when Stewie walks up to a Zoltar machine and says “I wish I was big.”
In the scene where Luke Perry is reading “every high school newspaper,” his “wife” calls from off-screen “Luke! Luke, time for dinner!”, quoting Aunt Beru from Star Wars: A New Hope when she calls him to dinner after he finds Leia’s message in R2.
In his interview with Meg, Adam West says "Got Milk?" and "I Gotcha, diagonally! Pretty sneaky, sis!" The first quote is the tagline of an ad campaign for milk. The second is from a commercial for the checkers game "Connect 4" by Milton Bradley.