This episode’s title is a reference to The Life Aquatic with Steve Zissou.
The scene in which Stewie visits the Institute of Chicago, erroneously referred to as the Chicago Museum of Art, is a direct homage to the film Ferris Bueller's Day Off. The painting Stewie stares into is Sunday Afternoon on the Island of La Grande Jatte by post-impressionist painter, Georges Seurat. The song accompanying this segment is the original from the film, and is a cover of the acoustic version of the song by The Dream Academy of “Please, Please, Please Let Me Get What I Want” by The Smiths.
When Herbert says his phone is ringing, he imitates the Nokia tune.
When Brian advises Stewie to “wait and see” whether or not he has cancer, Stewie says “Jim Henson had a wait and see attitude, and look what happened to him. Now we’ve got wrong-sounding Muppets,” a reference to Henson’s failure to properly address a cold he had, which led to pneumonia, and ultimately his death in 1990.
Dick Cheney is portrayed as a Wal-Mart greeter in a cutaway. He greets each customer with “Go fuck yourself,” a reference to a 2004 incident where he said those words to Senator Patrick Leahy after he asked the Vice-president about Halliburton’s alleged war profiteering.
In a parody of TaB soft drink commercials in the ’80s, after getting off his beach chair during a tan, Stewie drinks a can of TaB, then slowly looks at the camera.
A parody of Kellogg’s Frosted Flakes’ Tony the Tiger called Terry the Tiger is seen in the Griffin kitchen, saying “They’rrrrrrrrrre foooood!”