The name of the episode combines The Thin Blue Line, a colloquial term for the police, and “white lines,” a slang term for cocaine.
The way in which Mr. Weed hunts his employees is reminiscent of the famous 1924 short story The Most Dangerous Game by Richard Connell.
Mr. Weed says he has enough tranquilizer darts “to take-out Robert Downey, Jr.,” a reference to the actor’s drug problems. A rare self-chastising meta reference has Weed’s audience reacting with umbrage to the remark.
After Brian makes Quagmire realize he has made love to a man, he screams and runs away, similar to the film Ace Ventura: Pet Detective scene in which Ace realizes Lt Einhorn is actually Ray Finkel, whom Ace had kissed.
The next scene in which Brian and Joe catch a perp with cocaine is a reference to the 1977 TV series CHiPs. The CHiPs opening theme is also heard.
At the school assembly Brian is called “McGriffin, the Drug Dog,” a reference to the anti-crime mascot McGruff the Crime Dog.
After seeing some cocaine on his nose, Brian exclaims “Got Milk?”, a reference to the ad campaign. “Got Milk?” is also referenced near the beginning of the episode “Holy Crap”.
While time traveling, Chris finds himself in “the Bible days” and encounters an angry lion, a reference to the early persecution of Christians.