The title is a reference to the 1985 crime film To Live and Die in L.A., and is also a reference to the song “Dixie”: "I wish I was in Dixie, hurrah, hurrah; in Dixieland I’ll take my stand, to live and die in Dixie."
The plot of this episode is somewhat similar to the 1991 film, Cape Fear.
Chris gives Barbara a bottle of Elizabeth Taylor’s brand of perfume and says “I guess that means you’ll smell like bourbon and vicodin,” referring to the actress’s alleged substance abuse problems.
The FBI agents are a reference to The Odd Couple when they note “We’ll be watching your house together, even though he’s a slovenly liberal and I’m a fastidious conservative."
After Lois says that she made dinner with Shake 'N' Bake, Stewie says “And I helped!” a line directly from Shake ’n’ Bake commercials.
After Stewie plays a song on the banjo, he screams “I got blisters on me fingers!” which is what Ringo Starr screams at the end of The Beatles song “Helter Skelter.”
When the robber asks for the names of Peter and Brian, Peter claims he is “T. J. Hooker” and Brian is “McMillan and Wife,” referring to two television police dramas.
When Peter and Brian are being chased by the Civil War survivors one of them asks “Has anyone seen my foot?” This is a reference to a Jerky Boys skit in which Sol Rosenberg is selling Confederate memorabilia, one of the items being a Confederate foot.