The story of Nate Griffin is a reference to Roots: The Saga of an American Family. Tobi, the effeminate slave who refuses to accept his white name, is a reference to Roots character Kunta Kinte.
Peter reveals that his ancestor Nate Griffin’s real name is Richard Bachman, a reference to the pen name horror novelist Stephen King used earlier in his writing career.
A Quagmire character is shown, referred to as “Quagdingo”, a parody of Mandingo.
Nate’s flight in a cart pulled by a white bronco is a parody of the O.J. Simpson murder case, and he is picked up by Al Cowlings, who drove O.J.
The prank Nate Griffin pulls on the slave ship captain as well as the music is taken from Meatballs.
Judith Light accidentally took the oxygen tank instead of the Tony Danza breath. This refers to the Who’s the Boss? episode "First Kiss" where Tony and Angela kiss.
Peter’s great-great-grandfather “Black-Eye” Griffin starred in 1920s-era short films. The first silent film where he is looking at the moon is a reference to the film Le Voyage dans la Lune/A Trip to the Moon which was a black and white silent film from 1902.
When Peter is trying to sell the wheel to the cavemen, Brian says to Peter “You so money, don’t know it.” This is a reference from the movie Swingers, as Vince Vaughn says this to Jon Favreau throughout the movie to build his confidence.
After Lois helps Ur-Peter sell the wheel, he says to her, “You and I will party like it’s 9,” a reference to Prince’s song 1999.
When Peter Hitler is distracting his brother Adolf with childish antics while Adolf is making a speech at a rally, the scene parodies Rudy Giuliani’s inauguration speech as mayor of New York City and how Guiliani’s son Andrew was misbehaving, horse-playing and pantomiming his father during the speech.
Hitler becomes extremely annoyed when Peter asks if he was going to try art school again. This is a reference to Hitler's failed acceptance to an art school and to the theory that Hitler hated Jewish people because a Jewish professor had rejected his school candidacy in Vienna.
One of Peter Hitler's congrats sayings is "Yeah Germinater. 'I'll be back.'" refers to the Terminator's line "I'll be back" which is said by Arnold Schwarzenegger.