"Yug Ylimaf" was celebrated as the 200th production episode but this episode is the 200th episode to be broadcast.
This episode includes multiple plot lines instead of the standard two.
In the opening of the episode, Seamus' last name is revealed to be Levine and Herbert's first name is John.
This is the first episode in eight seasons where Daniel Palladino was credited as writer.
The episode is presented as being from the writer that wrote the Who’s the Boss? episode "where Tony's uncle dies and leaves him a vineyard." The episode in question is "Inherit the Wine" airing during the seventh season which was really written by Daniel Palladino.
Glenn Quagmire becomes "Glenda Vajmire" after becoming a woman.
It's revealed that Meg likes the band Coldplay. Meg also loses a conjoined twin and a kidney in this episode.
Without being specific, Stewie travels back to the "Summer of Love" and tells Lois that Sesame Street will be along in "a couple of years." The two events respectively occurred in 1967 and 1969.
"I Gotta Feeling" by the Black Eyed Peas is used for the opening theme.
The episode is said to feature songs by Maroon 5, Taylor Swift, Gin Blossoms, Jewel, James Blunt, Natalie Merchant, Hootie & the Blowfish, Goo Goo Dolls, Nelly Furtado, Xtreme, Shania Twain, Michael Bolton, Selena Gomez, Taylor Hicks, Joan Osborne, Jason Mraz, Katy Perry, Kelly Clarkson, Pussycat Dolls, Bruno Mars, Natalie Imbruglia, Alanis Morissette, Paula Cole, John Mayer, Train, Evanescence, Adele, Florence and the Machine, Gavin DeGraw, Josh Groban, Michael Buble, Sixpence None the Richer, Indigo Girls, The Cranberries, Savage Garden, Belinda Carlisle, Beyonce, The Rembrandts, Natasha Bedingfield, Dido, Duncan Sheik, Dispatch, Elliott Smith, Edwin McCain, Rufus Wainwright, Lady Gaga, Britney Spears, Jason Derulo, Corinne Bailey Rae, Rob Thomas, The Wallflowers, Demi Lovato, Big Time Rush, Third Eye Blind, Fastball, Oasis, Ben Folds Five, Keane, Gwen Stefani, Jordin Sparks, The Killers, K-Ci & JoJo, Boyz II Men, Nickelback, Leona Lewis, Gym Class Heroes, Carrie Underwood, The Bangles, Annie Lennox, The Proclaimers, Matchbox 20, UB40, and Ludacris featuring T.I.
The DVD commentary discusses several discarded story ideas including Glenn falling for the voice of an aircraft controller, only to reject her when she fails to meet his beauty standards, Seamus and Carl crashing a gay wedding, Al Harrington falling for a woman selling "Wacky Waving Inflatable Arm-Flailing Tubewoman" and Dr. Hartman in a Cinderella parody falling for a woman after giving her a pelvic exam but fails to get a look at her face. The stories presented were also often shortened from longer story ideas.