The title is a reference to a song from the 1960 Broadway musical Bye Bye Birdie.
When Derek heals the waiter's elbow, he does it in a similar way to the way Mr. Miyagi heals injuries in the original Karate Kid film.
The scene in which Lauren Conrad shows Brian her bio-molecular research is an almost exact replica of the scene in the film Star Trek II: The Wrath Of Khan in which Dr. Carol Marcus presents Phase Two of the Genesis project including similar music.
The hat Stewie wears when on the set with Brian and Lauren is the hat Eliza Doolittle wears in My Fair Lady.
Lauren states that America elected Bush, who is "not a smart person", twice. Brian then replies by saying "once." This is a reference to Al Gore's popular vote triumph over Bush in the 2000 presidential election while losing the electoral college.