Carter had previously mentioned having an affair and possibly having an illegitimate mulatto son in "Screwed the Pooch".
This is the actual 150th broadcast episode, an accolade given to "Brian & Stewie" based on production order.
Despite Quagmire's hatred for Brian, Brian is seen with Peter, Quagmire, and Joe in the Drunken Clam. However, Quagmire still expresses his dislike for Brian after he gives a suggestion.
This is the third episode without an appearance by Chris or Meg in the same episode.
This is the first episode that Stewie doesn't appear in. This made Brian the only character to appear in all episodes up until "In Harmony's Way", as Peter and Lois only appeared in the musical numbers of "Brian & Stewie", which were cut after the initial broadcasts.
Carter sends Babs a recording of "Jeepers Creepers".
"Begin the Beguine" by George Gershwin plays during the ballroom sequence.
When Babs is waking Carter up after Peter breaks into their house, Carter mumbles something in his sleep about simply taking Lois' temperature. This can be interpreted to mean that either Lois is nervous when she is sick, or Carter molested her when she was young.
Carter claims to have only seen the word "wind" written. This same joke is used in the fifteenth Simpsons Halloween episode when Marge says she's only read the word "wind" in books.
Similarly to "Tales of a Third Grade Nothing", a reference at the end to a Family Guy episode airing the following week is made untrue. This time FOX's coverage of baseball's National League Championship Series preempted Family Guy the week after this episode's initial airing.