William Shakespeare (April 1564 – 23 April 1616) was an English poet, playwright, and actor, regarded as the greatest writer in the English language.
Stewie auditions with the "winter of our discontent" soliloquy from Shakespeare's Richard III in "The King Is Dead", which he will repeat again in the beginning of "And the Wiener is...". Peter also imagines monkey's writing Shakespeare in "The King Is Dead".
Peter buys an erotic novel from the sex shop called Much Ado About Humping, a parody of the Shakespeare play Much Ado About Nothing.
Hamlet's soliloquy from Hamlet, Act III scene iii is featured in "Total Recall" during a Shakespeare In The Park.
In "Road to India", Brian notes that sometimes fame brings unwanted attention, setting up a cutaway gag in which Shakespeare is given grief by the townsfolk over his ruffled collar, until he returns to the store declaring it doesn't suite him.
From observing a worn copy of Shakespeare in Dr. Cecil Pritchfield's bookcase, Stewie notes that he must have read it extensively to his gay lover/husband Michael in "Send in Stewie, Please". As he is dying, the Dr. quotes Romeo and Juliet.