Wilmington is the largest city in the state of Delaware, United States, and is located at the confluence of the Christina River and Brandywine Creek, near where the Christina flows into the Delaware River. It is the county seat of New Castle County and one of the major cities in the Delaware Valley metropolitan area. Wilmington was named by Proprietor Thomas Penn for his friend Spencer Compton, Earl of Wilmington, who was prime minister in the reign of George II of Great Britain.

Both World Wars stimulated the city's industries. Industries vital to the war effort - shipyards, steel foundries, machinery, and chemical producers - operated on a 24-hour basis. Other industries produced such goods as automobiles, leather products, and clothing. In the 1980s, the city experienced tremendous job growth and office construction when many national banks and financial institutions relocated to the area after the Financial Center Development Act of 1981 substantially liberalized the laws governing banks operating within the state. In 1986, the state adopted legislation targeted at attracting international finance and insurance companies. Today, many national and international banks, including Bank of America, Chase, and Barclays, have operations in the city, with these typically being their credit card operations.

In "Stewie Goes for a Drive", Lindsay gets the lessor of two showcases on The Price is Right. Lindsay's showcase consists of a hammock, a box of chalk, and a trip to her parent's house in Wilmington, Delaware, as she laments rescheduling her abortion.