The Xbox 360 is the second video game console produced by Microsoft and the successor to the Xbox. The Xbox 360 competes with Sony's PlayStation 3 and Nintendo's Wii as part of the seventh generation of video game consoles.

In "April in Quahog", Peter Griffin buys an Xbox 360 to win his children's love back. He later plays the game Call of Duty: Modern Warfare 2 on Xbox Live, and doesn't let his children play on it.