• "Yug Ylimaf" is "Family Guy" spelled backwards. This episode continues a line of self-referencing titles.
  • Even though this is really the 192nd broadcast episode, it is celebrated as Family Guy's 200th episode. "Stewie Kills Lois", the 102nd broadcast episode, was hailed as the 100th, and "Brian & Stewie"; the 143rd broadcast episode, was touted as the 150th as FOX counts by production order rather than broadcast order. The 200th episode in broadcast order is "Valentine's Day in Quahog".
  • Brian brings up his two published novels Faster Than The Speed Of Love and Wish It, Want It, Do It..
  • This is the second time the birth of Stewie has been shown following "Chitty Chitty Death Bang".
  • This is the first appearance of the Greased-up Deaf Guy since "Model Misbehavior".
  • This episode contains two of the show's best-known running gags, Cleveland's Bathtub Gag and the chicken fights, played backwards.
  • Despite time running backwards, the characters still speak their lines forward. The DVD commentary mentions that subtitles were considered for backward dialog, but were discarded in favor of moments of normal speaking.
  • Stewie references Meg's original voice actress by saying, "Oh my God, you're Lacey Chabert," when it gets to where he, Meg, Chris, Peter, Lois, Brian, Carter, and Babs are in the living room after they came home after Stewie was born, which is contradictory to "Back to the Pilot", where he and Brian have no idea why Meg sounded different than she does in the present.
  • On a related note, this is Lacey Chabert's first new appearance as Meg ever since she quit the show.
  • Gary and Karen, a caveman and woman from "Jungle Love" appear in a cutaway.
  • The press materials had a photo of Brian taking a bar pickup on a date with Washington crossing the Delaware, but the scene did not end up in the broadcast version. The DVD commentary confirms this was cut for time, as was a scene of Brian having sex with a girl on Thomas Edison's work bench. Neither scene is included in the DVD deleted scenes.
  • Statler and Waldorf from The Muppet Show appear at Ford's Theater during the Lincoln assassination.
  • Chris asking of anyone heard infant Stewie talk are another nod to the long debate of whether the family can understand Stewie.
  • Episodes revisited in reverse include "The Blind Side" (Peter falling down the stairs), "8 Simple Rules for Buying My Teenage Daughter" (the ipecac scene), and "The Cleveland-Loretta Quagmire" (Peter and the barbershop quartet singing "You Have AIDS").
  • Stewie mentions German model Heidi Klum divorcing British R&B singer Seal because of his scarred face.
  • After Brian asks Meg about Stewie to Meg's puzzlement, Lois and Meg credit Brian for giving Stewie his name.
  • Brian uses a similar moment to determine the direction of time, Mort picking up a quarter on the street. First near the present, then near Stewie's birth.
  • Stewie claims that Ernie the Giant Chicken has a kid in his preschool.
  • Peter makes it clear that he and Lois had a rocky relationship prior to his birth by telling Stewie it was up to him to save the marriage when he came home from the hospital. It's also revealed that Peter was jealous of Stewie being the baby.
  • When Stewie is being "unborn" he has all of his regular hair but in "Chitty Chitty Death Bang", he was shown being born with no hair.
  • In the table read for this episode, after Brian said how he could not imagine life without Stewie, this dialog was exchanged:
Stewie: Well, after 200 episodes, it might be good to start imagining life without all of us, right?
Brian: Right, yes, absolutely.
Stewie: Lot on our plates. [1]
  • This episode was nominated for a MPSE Golden Reel Award for Outstanding Sound Editing for an Animated Television Program. [2]
  • In a deviation of always submitting for Comedy Series, this episode was submitted for Animated Program for the 65th Primetime Emmy Awards [3]
  • The DVD commentary notes that the scenes and music were not merely recorded and then reversed, but intentionally designed to sound and look like they were backwards as running the film backwards wasn't giving the true effect wanted.